Jana Karasova Selected Research

Poisoning

1/2010	Novel acetylcholinesterase reactivator--oxime K048--reactivation activity in vitro.
8/2009	A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice.
1/2009	An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice.
1/2009	A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats.
12/2008	A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice.
10/2008	The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun.
9/2008	A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats.
1/2008	An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
1/2008	A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
11/2007	The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.

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Jana Karasova Research Topics

Disease

13	Poisoning 01/2010 - 01/2007

Drug/Important Bio-Agent (IBA)

12	OximesIBA 08/2009 - 01/2007
10	tabunIBA 01/2010 - 01/2007
6	asoxime chloride (H16)IBA 01/2009 - 01/2007
5	Obidoxime Chloride (Obidoxime)IBA 01/2009 - 01/2007
4	Trimedoxime (Trimedoxime Bromide)IBA 12/2008 - 09/2007
3	cyclohexyl methylphosphonofluoridate (cyclosarin)IBA 01/2009 - 11/2007
3	Atropine FDA LinkGeneric 01/2009 - 01/2007
2	AntidotesIBA 01/2010 - 09/2007
2	Neuroprotective AgentsIBA 01/2009 - 01/2007
2	SomanIBA 09/2008 - 01/2007
2	AcetylcholinesteraseIBA 01/2008 - 01/2007